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lp-922056  (Merck KGaA)

 
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    Merck KGaA lp-922056
    Lp 922056, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lp-922056/lp+922056/pmc10866157-13-7-16
    Average 90 stars, based on 1 article reviews
    lp-922056 - by Bioz Stars, 2026-10
    90/100 stars

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    Article Snippet: The 5-aza-dC (a nonselective DNMT inhibitor) and LP-922056 (a selective Notum pectinacetylesterase inhibitor) were purchased from Merck KGaA (Darmstadt, Germany) and dissolved in dimethylsulfoxide (DMSO) at 25 mg/mL and 2 mg/mL concentrations, respectively.



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    lp 922056  (Bio-Techne corporation)
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    Bio-Techne corporation lp 922056
    Cortical neurons were transfected with FiNGR-PSD95-GFP to tag PSD95 endogenously. Control neurons were co-transfected with mem-mCh and showed strong PSD95 puncta localisation to protrusions ( A ), which is lost when neurons were co-transfected with memNotum ( B ) or when control cultures were incubated with soluble, recombinant Notum ( C ). Puncta expression could be rescued in memNotum transfected neurons by pre-treatment with Notum inhibitor <t>LP-922056</t> ( D ). ( E ) Quantification of protrusion number showed no difference between treatment groups, ( F ) PSD95-positive protrusion quantification. Neurons were stained for PSD95 and Bassoon (BSN) after transfection with either mem-mCh ( G ) or memNotum ( H ), and co-localised puncta in mCh-expressing protrusions were quantified ( K ). PSD95/BSN puncta (shown in the inset in G ) were significantly reduced in memNotum-transfected neurons compared to control, but not when control cultures were incubated with soluble, recombinant Notum ( I ). Puncta expression could be rescued in memNotum transfected neurons by pre-treatment with LP-922056 ( J ). Statistical significance was addressed using one-way ANOVA with Dunnett’s multiple comparison test to compare relevant controls within groups and Student’s t-test to compare specific combinations. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001. Experiments were performed in biological triplicate, with at least 5 fields/group were analysed/replicated.
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    https://www.bioz.com/product/lp-922056/LP+922056/bio_rxiv__2023__02__17__528927-112-11-8
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    Cortical neurons were transfected with FiNGR-PSD95-GFP to tag PSD95 endogenously. Control neurons were co-transfected with mem-mCh and showed strong PSD95 puncta localisation to protrusions ( A ), which is lost when neurons were co-transfected with memNotum ( B ) or when control cultures were incubated with soluble, recombinant Notum ( C ). Puncta expression could be rescued in memNotum transfected neurons by pre-treatment with Notum inhibitor LP-922056 ( D ). ( E ) Quantification of protrusion number showed no difference between treatment groups, ( F ) PSD95-positive protrusion quantification. Neurons were stained for PSD95 and Bassoon (BSN) after transfection with either mem-mCh ( G ) or memNotum ( H ), and co-localised puncta in mCh-expressing protrusions were quantified ( K ). PSD95/BSN puncta (shown in the inset in G ) were significantly reduced in memNotum-transfected neurons compared to control, but not when control cultures were incubated with soluble, recombinant Notum ( I ). Puncta expression could be rescued in memNotum transfected neurons by pre-treatment with LP-922056 ( J ). Statistical significance was addressed using one-way ANOVA with Dunnett’s multiple comparison test to compare relevant controls within groups and Student’s t-test to compare specific combinations. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001. Experiments were performed in biological triplicate, with at least 5 fields/group were analysed/replicated.

    Journal: bioRxiv

    Article Title: Wnt-7a-positive dendritic cytonemes induce synaptogenesis in cortical neurons

    doi: 10.1101/2023.02.17.528927

    Figure Lengend Snippet: Cortical neurons were transfected with FiNGR-PSD95-GFP to tag PSD95 endogenously. Control neurons were co-transfected with mem-mCh and showed strong PSD95 puncta localisation to protrusions ( A ), which is lost when neurons were co-transfected with memNotum ( B ) or when control cultures were incubated with soluble, recombinant Notum ( C ). Puncta expression could be rescued in memNotum transfected neurons by pre-treatment with Notum inhibitor LP-922056 ( D ). ( E ) Quantification of protrusion number showed no difference between treatment groups, ( F ) PSD95-positive protrusion quantification. Neurons were stained for PSD95 and Bassoon (BSN) after transfection with either mem-mCh ( G ) or memNotum ( H ), and co-localised puncta in mCh-expressing protrusions were quantified ( K ). PSD95/BSN puncta (shown in the inset in G ) were significantly reduced in memNotum-transfected neurons compared to control, but not when control cultures were incubated with soluble, recombinant Notum ( I ). Puncta expression could be rescued in memNotum transfected neurons by pre-treatment with LP-922056 ( J ). Statistical significance was addressed using one-way ANOVA with Dunnett’s multiple comparison test to compare relevant controls within groups and Student’s t-test to compare specific combinations. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001. Experiments were performed in biological triplicate, with at least 5 fields/group were analysed/replicated.

    Article Snippet: Treatments with 1μg/ml of recombinant human NOTUM protein (Bio-Techne) or 100nM LP-922056 (Kind gift from ARUK DDI) were performed for 48 h prior image acquisition.

    Techniques: Transfection, Incubation, Recombinant, Expressing, Staining, Comparison